There are many neurodegenerative disorders caused by a dysfunction of organelles. A significant portion of genetic neurodegenerative disorders are believed

There are many neurodegenerative disorders caused by a dysfunction of organelles. A significant portion of genetic neurodegenerative disorders are believed to be caused by defects in lysosomes. The Batten diseases are relevant examples as they are due to defects in lysosomal enzymes. Common effects of these diseases include developmental delays, seizures, movement disorders, and intellectual disabilities.

Which of the following describes an accurate scenario for a possible lysosomal storage disorder?
-Hydrolytic enzymes move from the lysosome into the cytoplasm, which results in an increase of the breakdown of metabolic waste in the cytoplasm.
-Inhibition of certain enzymes prevents the addition of a hydroxyl group to drug molecules, which results in an accumulation of exogenous toxins in the cell.
-Lack of phosphorylation prevents lysosomal proteins from being localized to the membrane of a lysosome, which results in an accumulation of toxic metabolites in the cell.
-A deficiency in transporter vesicles prevents the lysosome from secreting vesicles that contain protein transporters to the plasma membrane, which results in lack of surface transporters and cellular dysfunction.

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