There are many neurodegenerative disorders caused by a dysfunction of cellular organelles. Recent studies have looked at the role of

There are many neurodegenerative disorders caused by a dysfunction of cellular organelles. Recent studies have looked at the role of structural alterations in the Golgi apparatus within neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and Huntington’s. One study demonstrated that phosphorylation of a Golgi protein resulted in fragmentation and loss of structure of the Golgi apparatus.

Which of the following explains why the structure of the Golgi apparatus is so important to its function?
-The folding of the Golgi apparatus allows it to internalize macromolecules and sequentially degrade them as they traverse through the Golgi. Macromolecules are phagocytized on the cis face.
-The folding of the Golgi apparatus allows it to internalize macromolecules and sequentially degrade them as they traverse through the Golgi. Macromolecules are phagocytized on the trans face.
-The folding of the Golgi apparatus gives directionality. This allows macromolecules that traverse the Golgi apparatus to be sequentially modified along different compartments until they are ready for release on the cis face.
-The folding of the Golgi apparatus gives it some directionality. This allows macromolecules that traverse the Golgi apparatus to be sequentially modified along different compartments until they are ready for release on the trans face.

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